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Guangzhou Kafen Biotech Co.,Ltd
Guangzhou Kafen Biotech Co.,Ltd
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BP / USP Grade Vetoryl Trilostane Steroids Treatment Cushing Syndrome

BP / USP Grade Vetoryl Trilostane Steroids Treatment Cushing Syndrome

Brand Name : Kafen
Model Number : 13647-35-3
Certification : USP, GMP ,ISO9001, UKAS,BP
Place of Origin : Guangdong
MOQ : 10g
Price : negotiable
Payment Terms : D/A, L/C, D/P, T/T, Western Union, MoneyGram, Bitcoin
Supply Ability : 5000kg/month
Delivery Time : within 8 hours after receiving your payment
Packaging Details : Disguised and discreet or according to every customer's requirements
CAS : 13647-35-3
MF : C20H27NO3
MW : 329.4333
Appearance : White powder
Storage : Keep in dry and avoid light, heat and moisture
Suitable for : Adult or bodybuilders
Assay : 99%
Package : Disguised and discreet or according to every customer's requirements
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BP / USP Grade Vetoryl Trilostane Steroids Treatment Cushing Syndrome


1. Quick Details:


Product Name:Trilostane
Synonym: Vetoryl
CAS :13647-35-3
Molecular Formula:C20H27NO3
Molecular Weight:329.4333
Assay :99%
Grade : Pharmaceutical Grade
Storage: Shading, confined preservation
Appearance: White crystalline powder
Usage : Trilostane can inhibit cortical hormone in the process of synthesis of 3 beta dehydrogenase, make the cortisol, aldosterone synthesis decreased, clinically used in the treatment of Cushing syndrome (hypercortisolism) and primary aldosteronism. This product also had significantly effect to decreased serum testosterone level.


2 . Description:


Trilostane blocks an enzyme involved in the production of several steroids including cortisol. Inhibiting this enzyme inhibits the production of cortisol. In Cushing's syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions of the body, too much can cause problems. Trilostane reduces the amount of steroids produced by the adrenal gland.

Trilostane A drug that interferes with the natural synthesis of steroids and is used to treat breast cancer in post-menopausal women. A brand name is Modrenal.

A short-acting adrenocortical suppressant for oral use in dogs. Trilostane blocks the adrenal gland from making too many steroids. Although steroids are important for various functions of the body, too much can cause problems.


3 . Function:


Trilostane can inhibit cortical hormone in the process of synthesis of 3 beta dehydrogenase, make the cortisol, aldosterone synthesis decreased, clinically used in the treatment of Cushing syndrome (hypercortisolism) and primary aldosteronism. This product also had significantly effect to decreased serum testosterone level.

Trilostane is used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible.

Trilostane blocks an enzyme involved in the production of several steroids including cortisol. Inhibiting this enzyme inhibits the production of cortisol. In Cushing's syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions of the body, too much can cause problems. Trilostane reduces the amount of steroids produced by the adrenal gland.


Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5, 4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.


4 . COA :


Test ItemsSpecificationResults
IdentificationPositiveConfirm
Melting point257°C to 270°C261°C -266°C
AppearanceWhite to pale white solidWhite solid
Heavy metalsNo more than 20ppm10ppm
Loss on dryingNot more than 0.5%0.18%
Residue on IgnitionNot more than 0.1%0.02%

Solubility


soluble in dimethyl sulfoxideConforms
soluble in pyridineConforms
slightly soluble in ethanolConforms
slightly soluble in waterConforms
Assay (microbial)Not less than 99.0%99.5%
Specific Rotation+137-139°137.0°
Related impuritiesnot more than 1.0%0.35%
HPLC puritynot less than 99.0%99.6%
Solvent ResiduesEthanol<5000ppm1000ppm
ConclusionConforms with In-house standard.


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BP / USP Grade Vetoryl Trilostane Steroids Treatment Cushing Syndrome Images

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